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Chemical Structure : EP4R antagonist 77
Catalog No.: PC-21515Not For Human Use, Lab Use Only.
EP4R antagonist 77 is the sodium salt of EP4R antagonist 74, a potent, selective EP4 receptor antagonist with Ki of 11.2 nM.
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EP4R antagonist 77 is the sodium salt of EP4R antagonist 74, a potent, selective EP4 receptor antagonist with Ki of 11.2 nM.
EP4R antagonist 77 dose-dependently prevented mechanical hypersensitivity induced by an intraplantar injection of 10 μg of PGE2. EP4R antagonist 77 exhibited anti-allodynic and anti-inflammatory activity in several preclinical pain models in mice.
| M.Wt | 390.39 | |
| Formula | C20H20FN4NaO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gahbauer S, et al. Nat Commun. 2023 Dec 6;14(1):8067.
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