EP4R antagonist 77 | EP4 antagonist | Probechem Biochemicals

Chemical Structure : EP4R antagonist 77

EP4R antagonist 77 (EP4R antagonist 74 sodium salt)

Catalog No.: PC-21515Not For Human Use, Lab Use Only.

EP4R antagonist 77 is the sodium salt of EP4R antagonist 74, a potent, selective EP4 receptor antagonist with Ki of 11.2 nM.

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Biological Activity

EP4R antagonist 77 is the sodium salt of EP4R antagonist 74, a potent, selective EP4 receptor antagonist with Ki of 11.2 nM.
EP4R antagonist 77 dose-dependently prevented mechanical hypersensitivity induced by an intraplantar injection of 10 μg of PGE2. EP4R antagonist 77 exhibited anti-allodynic and anti-inflammatory activity in several preclinical pain models in mice.

Physicochemical Properties

M.Wt	390.39
Formula	C20H20FN4NaO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium 2-((8-fluoro-9H-pyrimido[4,5-b]indol-4-yl)amino)spiro[3.5]nonane-7-carboxylate

References

1. Gahbauer S, et al. Nat Commun. 2023 Dec 6;14(1):8067.

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EP4R antagonist 77 (EP4R antagonist 74 sodium salt)

Biological Activity

Physicochemical Properties

References

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