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Chemical Structure : EPIC-0628
Catalog No.: PC-21986Not For Human Use, Lab Use Only.
EPIC-0628 (EPIC0628) is a selective and potent inhibitor that selectively disrupts the HOTAIR-EZH2 interaction and promotes ATF3 expression, enhances the temozolomide efficacy in glioblastoma.
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EPIC-0628 (EPIC0628) is a selective and potent inhibitor that selectively disrupts the HOTAIR-EZH2 interaction and promotes ATF3 expression, enhances the temozolomide efficacy in glioblastoma.
EPIC-0628 suppresses the HOTAIR-mediated recruitment of EZH2 on the chromatin.
EPIC-0628 potentially and specifically inhibits the HOTAIR-EZH2 interaction in GBM cells, decreases the survival rate of GBM cells in a dose-dependent manner.
EPIC-0628 silences MGMT expression by promoting ATF3 expression, causes cell cycle arrest in GBM.
EPIC-0628 improves the sensitivity of TMZ by modulating the HR-linked ATF3-p38-E2F1 axis.
EPIC-0628 enhances the TMZ sensitivity in GBM orthotopic xenograft model.
| M.Wt | 391.37 | |
| Formula | C20H17F4N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yang E, et al. Cancer Lett. 2024 Mar 13:216812.
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