Chemical Structure : EPIC-0628
CAS No.:
EPIC-0628
(EPIC0628)
Catalog No.: PC-21986Not For Human Use, Lab Use Only.
EPIC-0628 (EPIC0628) is a selective and potent inhibitor that selectively disrupts the HOTAIR-EZH2 interaction and promotes ATF3 expression, enhances the temozolomide efficacy in glioblastoma.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
EPIC-0628 (EPIC0628) is a selective and potent inhibitor that selectively disrupts the HOTAIR-EZH2 interaction and promotes ATF3 expression, enhances the temozolomide efficacy in glioblastoma.
EPIC-0628 suppresses the HOTAIR-mediated recruitment of EZH2 on the chromatin.
EPIC-0628 potentially and specifically inhibits the HOTAIR-EZH2 interaction in GBM cells, decreases the survival rate of GBM cells in a dose-dependent manner.
EPIC-0628 silences MGMT expression by promoting ATF3 expression, causes cell cycle arrest in GBM.
EPIC-0628 improves the sensitivity of TMZ by modulating the HR-linked ATF3-p38-E2F1 axis.
EPIC-0628 enhances the TMZ sensitivity in GBM orthotopic xenograft model.
Physicochemical Properties
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M.Wt
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391.37
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Formula
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C20H17F4N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(3-(4-fluorophenoxy)benzyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine
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References
1. Yang E, et al. Cancer Lett. 2024 Mar 13:216812.
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