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Chemical Structure : ER-000444793
CAS No.: 792957-74-5
Catalog No.: PC-62132Not For Human Use, Lab Use Only.
ER-000444793 is a potent, cyclophilin D-independent inhibitor of mitochondrial permeability transition pore (mPTP) with with IC50 of 2.8 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ER-000444793 is a potent, cyclophilin D-independent inhibitor of mitochondrial permeability transition pore (mPTP) with with IC50 of 2.8 uM.
ER-000444793 neither affects cyclophilin D (CypD) enzymatic activity, nor displaces CsA from CypD protein.
ER-000444793 improves mitochondrial Ca2+ tolerance with IC50 of 1.2 uM, increases mitochondrial Ca2+ retention capacity dose-dependently, and delays the onset of mPT in HeLa S3 cells with no effect on mitochondrial or cellular health.
| M.Wt | 354.409 | |
| Formula | C23H18N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,2-Dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-4-quinolinecarboxamide |
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1. Briston T, et al. Sci Rep. 2016 Nov 25;6:37798.
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