You are here:Home-Chemical Inhibitors & Agonists-Others-Mitochondrial Permeability Transition Pore (mPTP)-ER-000444793
ER-000444793

Chemical Structure : ER-000444793

CAS No.: 792957-74-5

ER-000444793 (ER000444793)

Catalog No.: PC-62132Not For Human Use, Lab Use Only.

ER-000444793 is a potent, cyclophilin D-independent inhibitor of mitochondrial permeability transition pore (mPTP) with with IC50 of 2.8 uM.

Packing Price Stock Quantity
5 mg $148 In stock
10 mg $228 In stock
25 mg $388 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ER-000444793 is a potent, cyclophilin D-independent inhibitor of mitochondrial permeability transition pore (mPTP) with with IC50 of 2.8 uM.
ER-000444793 neither affects cyclophilin D (CypD) enzymatic activity, nor displaces CsA from CypD protein.
ER-000444793 improves mitochondrial Ca2+ tolerance with IC50 of 1.2 uM, increases mitochondrial Ca2+ retention capacity dose-dependently, and delays the onset of mPT in HeLa S3 cells with no effect on mitochondrial or cellular health.

Physicochemical Properties

M.Wt 354.409
Formula C23H18N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,2-Dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-4-quinolinecarboxamide

References

1. Briston T, et al. Sci Rep. 2016 Nov 25;6:37798.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: