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Chemical Structure : ER-464195-01
Catalog No.: PC-35072Not For Human Use, Lab Use Only.
ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5.
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ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5.
ER-464195-01 dose-dependently and specificly inhibits GST-fused CRT proteins binding to ITGA4 in vitro pull-down assay.
ER-464195-01 inhibits the PMA-induced T cells and the fMLP-stimulated neutrophils bound to VCAM1 (IC50=0.15 μM) and ICAM-1 (IC50=0.19 μM), respectively.
ER-464195-01 suppresses the cell adhesion and the migration of leukocytes, prevents colitis and downregulates the expression of inflammation-related genes in DSS-treated mice, ameliorates the severity of disease in IBD mouse models.
| M.Wt | 379.029 | |
| Formula | C23H39ClN2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ohkuro M, et al. Nat Commun. 2018 May 17;9(1):1982.
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