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ER-851

Chemical Structure : ER-851

CAS No.: 2685738-33-2

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ER-851 (ER851, ER-001259851-000)

Catalog No.: PC-72059Not For Human Use, Lab Use Only.

ER-851 (ER-001259851-000) is a potent, selective, orally active Axl inhibitor with IC50 of 5.2 nM in cell free assays, displays >35-fold selectivity against Mer (IC50=190 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ER-851 (ER-001259851-000) is a potent, selective, orally active Axl inhibitor with IC50 of 5.2 nM in cell free assays, displays >35-fold selectivity against Mer (IC50=190 nM).
    ER-001259851-000 shows a promising pharmacokinetic profile in mice.

    Physicochemical Properties

    M.Wt 668.774
    Formula C36H41FN8O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Month
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-cyclopentyl-N-(3-fluoro-4-((7-((1-methylpiperidin-4-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)oxy)phenyl)-3-(5-methylpyridin-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

    References

    1. Satoshi Inoue, et al. Bioorg Med Chem Lett. 2021 Sep 15;48:128247.

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