ERAP1 inhibitor 3

You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Aminopeptidase-ERAP1 inhibitor 3

Chemical Structure : ERAP1 inhibitor 3

Catalog No.: PC-72272Not For Human Use, Lab Use Only.

ERAP1 inhibitor 3 is a selective, small molecule inhibitor of ERAP1 with IC50 of 0.4 uM, displays no inhibitory effect against its paralogues ERAP2 and IRAP.

Packing	Price	Stock	Quantity
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ERAP1 inhibitor 3 is a selective, small molecule inhibitor of ERAP1 with IC50 of 0.4 uM, displays no inhibitory effect against its paralogues ERAP2 and IRAP.
ERAP1 inhibitor 3 allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activity toward a nonamer peptide representative of physiological substrates.
ERAP1 inhibitor 3 inhibited antigen presentation in a cellular assay.
Compound 3 displays higher potency for an ERAP1 variant associated with increased risk of autoimmune disease.

Physicochemical Properties

M.Wt	458.452
Formula	C20H21F3N2O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
Shipping
Solubility
Chemical Name/SMILES

References

1. Zachary Maben, et al. J Med Chem. 2020 Jan 9;63(1):103-121.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com