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Chemical Structure : ERD-308
CAS No.: 2320561-35-9
Catalog No.: PC-73165Not For Human Use, Lab Use Only.
ERD-308 (ERD308) is a highly potent estrogen receptor (ER) PROTAC degrader with DC50 of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 25 mg | $628 | In stock | |
| 100 mg | $1580 | In stock | |
| 1 g | Get quote |
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ERD-308 (ERD308) is a highly potent estrogen receptor (ER) PROTAC degrader with DC50 of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively.
ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in MCF-7 and T47D ER+ breast cancer cell lines.
ERD-308 induces more complete ER degradation than fulvestrant, the only approved selective ER degrader (SERD), and is more effective in inhibition of cell proliferation than fulvestrant in MCF-7 cells.
| M.Wt | 1004.26 | |
| Formula | C55H65N5O9S2 | |
| Appearance | Solid | |
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1. Jiantao Hu, et al. J Med Chem. 2019 Feb 14;62(3):1420-1442.
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