Catalog No.: PC-73165Not For Human Use, Lab Use Only.
ERD-308 (ERD308) is a highly potent estrogen receptor (ER) PROTAC degrader with DC50 of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively.
ERD-308 (ERD308) is a highly potent estrogen receptor (ER) PROTAC degrader with DC50 of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in MCF-7 and T47D ER+ breast cancer cell lines. ERD-308 induces more complete ER degradation than fulvestrant, the only approved selective ER degrader (SERD), and is more effective in inhibition of cell proliferation than fulvestrant in MCF-7 cells.
Physicochemical Properties
M.Wt
1004.26
Formula
C55H65N5O9S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility
Chemical Name/SMILES
References
1. Jiantao Hu, et al. J Med Chem. 2019 Feb 14;62(3):1420-1442.
