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Chemical Structure : ERDRP-0519
CAS No.: 1374006-96-8
Catalog No.: PC-72591Not For Human Use, Lab Use Only.
ERDRP-0519 (ERDRP0519) is a specific, orally bioavailable small-molecule viral polymerase inhibitor (CDV/MeV polymerase IC50=0.4/0.6 uM), shows pan-morbillivirus inhibitory activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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ERDRP-0519 (ERDRP0519) is a specific, orally bioavailable small-molecule viral polymerase inhibitor (CDV/MeV polymerase IC50=0.4/0.6 uM), shows pan-morbillivirus inhibitory activity.
ERDRP-0519 displayed vitro efficacy against a panel of MeV isolates representing seven distinct, currently endemic genotypes with EC50 values of 0.07-0.3 uM.
ERDRP-0519 potently inhibited morbillivirus-derived polymerase complexes, does not inhibit a distant member of the paramyxovirus family, respiratory syncytial virus (RSV).
ERDRP-0519 demonstrated oral efficacy gainst pathogenic CDV in ferrets.
ERDRP-0519 inhibits all phosphodiester bond formation in both de novo initiation of RNA synthesis at the promoter and RNA elongation by a committed polymerase complex.
ERDRP-0519 prevents measles virus (MeV) infection in squirrel monkeys (Saimiri sciureus).
ERDRP-0519 inhibits feline coronavirus (FCoV) in vitro.
| M.Wt | 529.579 | |
| Formula | C23H30F3N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO (52.9 mg/mL) |
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| Chemical Name/SMILES |
1-Methyl-N-[4-[[(2S)-2-[2-(4-morpholinyl)ethyl]-1-piperidinyl]sulfonyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide |
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1. Stefanie A Krumm, et al. Sci Transl Med. 2014 Apr 16;6(232):232ra52.
2. Kevin Wittwer, et al. Nat Commun. 2021 Sep 2;12(1):5233.
3. Cox RM, et al. PLoS Pathog. 2021 Feb 23;17(2):e1009371.
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