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ETC-206

Chemical Structure : ETC-206

CAS No.: 1464151-33-4

ETC-206 (Tinodasertib;ETC206;ETC 206;ETC-1907206)

Catalog No.: PC-63366Not For Human Use, Lab Use Only.

ETC-206 (Tinodasertib, ETC-1907206) is a potent, selective MNK1/2 inhibitor with IC50 of 64/86 nM, inhibits eIF4E phosphorylation inhibition in HeLa cell line with IC50 of 321 nM.

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Purity & Documentation Purity: 99.9% (LCMS) Select Batch:

Biological Activity

ETC-206 (Tinodasertib, ETC-1907206) is a potent, selective MNK1/2 inhibitor with IC50 of 64/86 nM, inhibits eIF4E phosphorylation inhibition in HeLa cell line with IC50 of 321 nM.
ETC-206 (Tinodasertib) displays excellent kinase selectivity, inhibits only 2 kinases by >65% at 1 uM against a panel of 104 kinases.
ETC-206 (Tinodasertib) demonstrates potent anti-proliferative activity against 25 hematological cancer cell lines with submicromolar IC50, especially against GK-5, DOHH2, AHH1 and P3HR-1 cell lines.
ETC-206 (Tinodasertib) prevents BC CML LSC self-renewal in vitro, significantly enhances the anti-tumor activity of dasatinib in BC CML mouse xenograft model.

Physicochemical Properties

M.Wt 408.461
Formula C25H20N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile

References

1. Yang HY, et al. J Med Chem. 2018 Apr 23. doi: 10.1021/acs.jmedchem.7b01714.

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