Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ETC-206
CAS No.: 1464151-33-4
Catalog No.: PC-63366Not For Human Use, Lab Use Only.
ETC-206 (Tinodasertib, ETC-1907206) is a potent, selective MNK1/2 inhibitor with IC50 of 64/86 nM, inhibits eIF4E phosphorylation inhibition in HeLa cell line with IC50 of 321 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ETC-206 (Tinodasertib, ETC-1907206) is a potent, selective MNK1/2 inhibitor with IC50 of 64/86 nM, inhibits eIF4E phosphorylation inhibition in HeLa cell line with IC50 of 321 nM.
ETC-206 (Tinodasertib) displays excellent kinase selectivity, inhibits only 2 kinases by >65% at 1 uM against a panel of 104 kinases.
ETC-206 (Tinodasertib) demonstrates potent anti-proliferative activity against 25 hematological cancer cell lines with submicromolar IC50, especially against GK-5, DOHH2, AHH1 and P3HR-1 cell lines.
ETC-206 (Tinodasertib) prevents BC CML LSC self-renewal in vitro, significantly enhances the anti-tumor activity of dasatinib in BC CML mouse xenograft model.
| M.Wt | 408.461 | |
| Formula | C25H20N4O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile |
|
1. Yang HY, et al. J Med Chem. 2018 Apr 23. doi: 10.1021/acs.jmedchem.7b01714.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
