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Chemical Structure : EU-5346
CAS No.: 315698-17-0
Catalog No.: PC-38265Not For Human Use, Lab Use Only.
EU-5346 (ML311) is a small molecule Mcl-1 inhibitor with IC50 of 0.31 uM, potently and selectively disrupts Mcl-1/Bim interaction.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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EU-5346 (ML311) is a small molecule Mcl-1 inhibitor with IC50 of 0.31 uM, potently and selectively disrupts Mcl-1/Bim interaction.
EU-5346 induced cell death and decreased spheroid formation in Her2-positive BC cells.
EU-5346 induced ubiquitination of Mcl-1- bound Her2 demonstrating a previously unknown role for Mcl-1 to stabilize Her2 protein levels.
When combined with tamoxifen or trastuzumab, EU-5346 induced significant anti-BC activity in hormone receptor positive or Her2-positive BC cells, respectively.
EU-5346 in combination with paclitaxel induced synergistic anti-BC activity in both paclitaxel-sensitive and paclitaxel-resistant TNBC cells.
| M.Wt | 415.46 | |
| Formula | C23H24F3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
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| Chemical Name/SMILES |
7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol |
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1. Bannister T, et al. Probe Reports from the NIH Molecular Libraries Program [Internet] 2012.
2. Bashari MH, et al. Breast Cancer Res. 2016 Feb 26;18(1):26.
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