EU1180-560

Chemical Structure : EU1180-560

Catalog No.: PC-26280Not For Human Use, Lab Use Only.

EU1180-560 is a subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 2.6 uM, with no detectable effect on GluN1/GluN3B receptors.

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Biological Activity

EU1180-560 is a subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 2.6 uM, with no detectable effect on GluN1/GluN3B receptors.
EU1180-560 produce noncompetitive, voltage-independent inhibition, consistent with a negative allosteric modulation mechanism.
EU1180-560 shows little to no effect on GluN1/GluN2-containing NMDA, AMPA, GABA, glycine, P2X, and kainate receptors.

Physicochemical Properties

M.Wt	435.50
Formula	C26H26FNO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-fluoro-2-(1-(4-isopropoxyphenyl)-2-(4-methoxyphenoxy)ethyl)isoindolin-1-one

References

1. Jacobs L, et al. Mol Pharmacol. 2026 Jan 29;108(3):100104.

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EU1180-560

Biological Activity

Physicochemical Properties

References

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