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EU1180-560

Chemical Structure : EU1180-560

CAS No.: 2677758-09-5

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EU1180-560

Catalog No.: PC-26280Not For Human Use, Lab Use Only.

EU1180-560 is a subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 2.6 uM, with no detectable effect on GluN1/GluN3B receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EU1180-560 is a subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 2.6 uM, with no detectable effect on GluN1/GluN3B receptors.
    EU1180-560 produce noncompetitive, voltage-independent inhibition, consistent with a negative allosteric modulation mechanism.
    EU1180-560 shows little to no effect on GluN1/GluN2-containing NMDA, AMPA, GABA, glycine, P2X, and kainate receptors.

    Physicochemical Properties

    M.Wt 435.50
    Formula C26H26FNO4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-fluoro-2-(1-(4-isopropoxyphenyl)-2-(4-methoxyphenoxy)ethyl)isoindolin-1-one

    References

    1. Jacobs L, et al. Mol Pharmacol. 2026 Jan 29;108(3):100104.

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