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Chemical Structure : EU1794-4
Catalog No.: PC-21035Not For Human Use, Lab Use Only.
EU1794-4 is a negative allosteric modulator of NMDA receptors, inhibits all GluN1/GluN2 combinations with IC50 of 0.28-3.1 uM.
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EU1794-4 is a negative allosteric modulator of NMDA receptors, inhibits all GluN1/GluN2 combinations with IC50 of 0.28-3.1 uM.
EU1794-4 reduces the Ca2+ permeability relative to monovalent cations of GluN1/GluN2A receptors.
EU1794-4 is a prototype for a new class of NMDA receptor negative allosteric modulators that reduce both the overall current that flows after receptor activation and the flux of Ca2+ ion relative to monovalent cations.
| M.Wt | 381.47 | |
| Formula | C16H19N3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Perszyk RE, et al. Mol Pharmacol. 2021 May;99(5):399-411.
2. Katzman BM, et al. Bioorg Med Chem Lett 25:5583–5588.
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