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EU1794-4

Chemical Structure : EU1794-4

CAS No.: 305373-14-2

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EU1794-4 (EU 1794-4)

Catalog No.: PC-21035Not For Human Use, Lab Use Only.

EU1794-4 is a negative allosteric modulator of NMDA receptors, inhibits all GluN1/GluN2 combinations with IC50 of 0.28-3.1 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

EU1794-4 is a negative allosteric modulator of NMDA receptors, inhibits all GluN1/GluN2 combinations with IC50 of 0.28-3.1 uM.
EU1794-4 reduces the Ca2+ permeability relative to monovalent cations of GluN1/GluN2A receptors.
EU1794-4 is a prototype for a new class of NMDA receptor negative allosteric modulators that reduce both the overall current that flows after receptor activation and the flux of Ca2+ ion relative to monovalent cations.

Physicochemical Properties

M.Wt 381.47
Formula C16H19N3O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(C1=C(NC(CC(SC(N2)=N)C2=O)=O)SC3=C1CCCC3)OCC

References

1. Perszyk RE, et al. Mol Pharmacol. 2021 May;99(5):399-411.

2. Katzman BM, et al. Bioorg Med Chem Lett 25:5583–5588.

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