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EU1794-4

Chemical Structure : EU1794-4

CAS No.: 305373-14-2

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EU1794-4 (EU 1794-4)

Catalog No.: PC-21035Not For Human Use, Lab Use Only.

EU1794-4 is a negative allosteric modulator of NMDA receptors, inhibits all GluN1/GluN2 combinations with IC50 of 0.28-3.1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EU1794-4 is a negative allosteric modulator of NMDA receptors, inhibits all GluN1/GluN2 combinations with IC50 of 0.28-3.1 uM.
    EU1794-4 reduces the Ca2+ permeability relative to monovalent cations of GluN1/GluN2A receptors.
    EU1794-4 is a prototype for a new class of NMDA receptor negative allosteric modulators that reduce both the overall current that flows after receptor activation and the flux of Ca2+ ion relative to monovalent cations.

    Physicochemical Properties

    M.Wt 381.47
    Formula C16H19N3O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl 2-(2-(2-imino-4-oxothiazolidin-5-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

    References

    1. Perszyk RE, et al. Mol Pharmacol. 2021 May;99(5):399-411.

    2. Katzman BM, et al. Bioorg Med Chem Lett. 25:5583–5588.

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