EU93-108

Chemical Structure : EU93-108

Catalog No.: PC-26193Not For Human Use, Lab Use Only.

EU93-108 is a potent, brain penetrant GluN2B-selective negative allosteric modulator (NAM) of NMDA receptor with IC50 of 0.557 uM (GluN1/GluN2B), with limited activity against GluN1/GluN2A, GluN1/GluN2C and GluN1/GluN2D

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Biological Activity

Physicochemical Properties

M.Wt	441.49
Formula	C20H25F2N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4-(3-(4-(3,4-difluorophenyl)piperazin-1-yl)-2-hydroxypropoxy)phenyl)methanesulfonamide

References

1. Harris LD, et al. ACS Chem Neurosci. 2023 Mar 1;14(5):917-935.

2. Yuan H, et al. Neuron. 2015 Mar 18;85(6):1305-1318.

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EU93-108

Biological Activity

Physicochemical Properties

References

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