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Chemical Structure : EX00000246
Catalog No.: PC-20445Not For Human Use, Lab Use Only.
EX00000246 is a highly potent TGR5 (GPBAR1) agonist with EC50 of 2 nM in AlphaScreen cAMP assays.
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EX00000246 is a highly potent TGR5 (GPBAR1) agonist with EC50 of 2 nM in AlphaScreen cAMP assays.
EX00000246 (500 nM) reduces cytokine production induced by various TLR ligands in human monocytes, also reduces CCL2, IL-12p70, and CXCL10, does not limit LPS induced IL-1β and IL-6 production.
EX00000246 modulates a subset of LPS activated genes and blocks M1 differentiation in human monocytes.
| M.Wt | 393.42 | |
| Formula | C22H20FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nuruddeen D Lewis, et al. PLoS One. 2014 Jun 26;9(6):e100883.
2. PCT WO 2010/016552 A1.
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