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Ebio3

Chemical Structure : Ebio3

CAS No.:

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Ebio3

Catalog No.: PC-23869Not For Human Use, Lab Use Only.

Ebio3 is a potent, subtype-selective inhibitor of potassium channel KCNQ2 (Kv7.2), efficiently suppresses KCNQ2 currents with IC50 of 1.2 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Ebio3 is a potent, subtype-selective inhibitor of potassium channel KCNQ2 (Kv7.2), efficiently suppresses KCNQ2 currents with IC50 of 1.2 nM.
Ebio3 shows no effect on the KCNQ1 channel, weakly inhibits KCNQ3, KCNQ4 and KCNQ5 (IC50=15-196 nM), and negligible inhibitory effects on K+, Na+, Ca2+ and H+ channels, including hERG, Kv4.2, TREK1, TREK2, TASK3, NaV1.1, CaV3.2 and Hv1.
Ebio3 inhibits KCNQ2 pathogenic GOF variants, 10 nM Ebio3 resulted in approximately 80% or greater reduction in the outward current for R75C and I238L mutations.

Physicochemical Properties

M.Wt 363.41
Formula C19H23F2N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(7-(difluoromethoxy)-1-(prop-2-yn-1-yl)-1H-indazol-3-yl)-2-propylpentanamide

References

1. Li J, et al. Nat Chem Biol. 2025 Jan 15. doi: 10.1038/s41589-024-01834-8.

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