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Eclitasertib

Chemical Structure : Eclitasertib

CAS No.: 2125450-76-0

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Eclitasertib (DNL-758, SAR-443122, DNL758, SAR443122)

Catalog No.: PC-72533Not For Human Use, Lab Use Only.

Eclitasertib (DNL-758, SAR-443122) is a potent, orally bioavailable, small-molecule RIPK1 inhibitor with IC50 of <1 uM, shows anti-necroptosis activity on U937 human cell line with pIC50 of 7.91.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Eclitasertib (DNL-758, SAR-443122) is a potent, orally bioavailable, small-molecule RIPK1 inhibitor with IC50 of <1 uM, shows anti-necroptosis activity on U937 human cell line with pIC50 of 7.91.

Physicochemical Properties

M.Wt 378.39
Formula C19H18N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

References

1. WO2017136727A2, Example 42.
2. Levente Petró J, et al. Bioorg Med Chem Lett. 2024 Nov 15;113:129970.

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