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Chemical Structure : Edicotinib
CAS No.: 1142363-52-7
Catalog No.: PC-61373Not For Human Use, Lab Use Only.
Edicotinib (JNJ-40346527, PRV 6527) is a potent, selective, orally bioavailable CSF-1R inhibitor with IC50 of 3.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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Edicotinib (JNJ-40346527, PRV 6527) is a potent, selective, orally bioavailable CSF-1R inhibitor with IC50 of 3.2 nM.
Edicotinib (JNJ-40346527) shows weak affinity for KIT and FLT3 (IC50= 20 nM and 190 nM, respectively).
Edicotinib (JNJ-40346527) reduces the levels of EMT-associated genes, stem cell markers and chemoresistance genes, produces strong chemo-sensitizing effects in vitro and in vivo.
| M.Wt | 461.61 | |
| Formula | C27H35N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamide |
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1. von Tresckow B, et al. Clin Cancer Res. 2015 Apr 15;21(8):1843-50.
2. Genovese MC, et al. J Rheumatol. 2015 Oct;42(10):1752-60.
3. Pass HI, et al. Oncotarget. 2016 Aug 30;7(35):56408-56421.
4. Kumar V, et al. Cancer Cell. 2017 Nov 13;32(5):654-668.e5.
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