Chemical Structure : Edoxaban
CAS No.:
480449-70-5
Edoxaban
(DU-176)
Catalog No. : PC-42502Not For Human Use, Lab Use Only.
A potent and orally active Factor Xa inhibitor with Ki of 0.561 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4250201
Biological Activity
A potent and orally active Factor Xa inhibitor with Ki of 0.561 nM; also inhibits prothrombinase (Ki=2.98 nM), weakly inhibits thrombin and FIXa (Ki=6.0 uM, and 41.7 uM); exhibits >10,000-fold selectivity for Fxa over FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin and chymotrypsin; inhibits thrombus formation in rat and rabbit thrombosis models.
Thrombosis
Approved
Physicochemical Properties
M.Wt
548.0575
Formula
C24H30ClN7O4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-
References
1. Furugohri T, et al. J Thromb Haemost. 2008 Sep;6(9):1542-9.
2. Furugohri T, et al. Eur J Pharmacol. 2012 Jul 5;686(1-3):74-80.
3. Morishima Y, et al. Thromb Res. 2013 Jan;131(1):59-63.
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