Edoxaban tosylate (DU-176b)

Chemical Structure : Edoxaban tosylate

CAS No.: 480449-71-6

Catalog No.: PC-42503Not For Human Use, Lab Use Only.

Edoxaban tosylate (DU-176b) is a potent and orally active Factor Xa inhibitor with Ki of 0.561 nM.

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10 mg	$58	In stock
50 mg	$98	In stock
100 mg	$148	In stock
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Biological Activity

Edoxaban tosylate (DU-176b) is a potent and orally active Factor Xa inhibitor with Ki of 0.561 nM.
Edoxaban also inhibits prothrombinase (Ki=2.98 nM), weakly inhibits thrombin and FIXa (Ki=6.0 uM, and 41.7 uM).
Edoxaban exhibits >10,000-fold selectivity for Fxa over FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin and chymotrypsin; inhibits thrombus formation in rat and rabbit thrombosis models.

Physicochemical Properties

M.Wt	720.2591
Formula	C31H38ClN7O7S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO
Chemical Name/SMILES	Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate (1:1)

References

1. Furugohri T, et al. J Thromb Haemost. 2008 Sep;6(9):1542-9.

2. Furugohri T, et al. Eur J Pharmacol. 2012 Jul 5;686(1-3):74-80.

3. Morishima Y, et al. Thromb Res. 2013 Jan;131(1):59-63.