Efonidipine hydrochloride monoethanolate |CAS:111011-76-8 Probechem Biochemicals

Chemical Structure : Efonidipine hydrochloride monoethanolate

CAS No.: 111011-76-8

Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate)

Catalog No.: PC-43070Not For Human Use, Lab Use Only.

Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker, exhibits antihypertensive effect through vasodilatation.

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10 mg	$75	In stock
50 mg	$255	In stock
100 mg	$455	In stock
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Biological Activity

Efonidipine (NZ-105) is a potent, dual T-type and L-type calcium channel blocker, exhibits antihypertensive effect through vasodilatation; increases coronary blood flow by blocking L & T-type calcium channels and attenuates myocardial ischaemia, lowers blood pressure in cerebral resistance vessels and prevents hypertension induced brain damage; increases glomerular filtration rate without increasing intra-glomerular pressure and filtration fraction.

Physicochemical Properties

M.Wt	714.1846
Formula	C36H45ClN3O8P
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 8.5 mg/mL
Chemical Name/SMILES	3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, hydrochloride, compd. with 2-[phenyl(phenylmethyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2

References

1. Masuda Y, et al. Arch Int Pharmacodyn Ther. 1990 Mar-Apr;304:247-64.

2. Tamura T, et al. Naunyn Schmiedebergs Arch Pharmacol. 1991 Apr;343(4):405-10.

3. Shudo C, et al. Gen Pharmacol. 1994 Nov;25(7):1451-8.

4. Yamashita T, et al. Jpn J Pharmacol. 1991 Nov;57(3):337-48.

Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate)

Biological Activity

Physicochemical Properties

References

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