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Chemical Structure : Eggmanone
Catalog No.: PC-62180Not For Human Use, Lab Use Only.
Eggmanone is a potent, selective inhibitor of PDE4 with (IC50=72 nM) that antagonizes the Hedgehog signaling pathway.
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Eggmanone (EGM1) is a potent, selective inhibitor of PDE4 with (IC50=72 nM) that antagonizes the Hedgehog signaling pathway;.
Eggmanone displays 40-50-fold selectiviyt over PDE3, PDE10, and PDE11.
Eggmanone causes selective activation of protein kinase A, regulates Gli processing and translocation, and inhibits the increase in the fraction of Gli2FL in the nucleus stimulated by SAG.
| M.Wt | 416.572 | |
| Formula | C20H20N2O2S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hempel JE, et al. Bioorg Med Chem Lett. 2016 Apr 15;26(8):1947-53.
2. Williams CH, et al. Cell Rep. 2015 Apr 7;11(1):43-50.
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