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Eggmanone

Chemical Structure : Eggmanone

CAS No.: 505068-32-6

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Eggmanone (EGM1)

Catalog No.: PC-62180Not For Human Use, Lab Use Only.

Eggmanone is a potent, selective inhibitor of PDE4 with (IC50=72 nM) that antagonizes the Hedgehog signaling pathway.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Eggmanone (EGM1) is a potent, selective inhibitor of PDE4 with (IC50=72 nM) that antagonizes the Hedgehog signaling pathway;.
    Eggmanone displays 40-50-fold selectiviyt over PDE3, PDE10, and PDE11.
    Eggmanone causes selective activation of protein kinase A, regulates Gli processing and translocation, and inhibits the increase in the fraction of Gli2FL in the nucleus stimulated by SAG.

    Physicochemical Properties

    M.Wt 416.572
    Formula C20H20N2O2S3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5,6,7,8-tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

    References

    1. Hempel JE, et al. Bioorg Med Chem Lett. 2016 Apr 15;26(8):1947-53.

    2. Williams CH, et al. Cell Rep. 2015 Apr 7;11(1):43-50.

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