Elacridar hydrochloride | P-gp inhibitor

Chemical Structure : Elacridar hydrochloride

CAS No.: 143851-98-3

Elacridar hydrochloride (GF-120918A)

Catalog No.: PC-45888Not For Human Use, Lab Use Only.

Elacridar hydrochloride is a potent inhibitor of multidrug resistance (MDR, P-gp) that fully reverses multidrug resistance CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and vincristine with IC50 of 0.02 uM.

Packing	Price	Stock
25 mg	$128	In stock
50 mg	$198	In stock
100 mg	$298	In stock
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Biological Activity

Elacridar hydrochloride is a potent inhibitor of multidrug resistance (MDR, P-gp) that fully reverses multidrug resistance CHRC5, OV1/DXR and MCF7/ADR cells to the cytotoxicity of doxorubicin and vincristine with IC50 of 0.02 uM.
Elacridar effectively competes with [3H]azidopine for binding P-glycoprotein.
Elacridar restores sensitivity of the tumor to a single dose of doxorubicin in mice; orally bioavailable.

Physicochemical Properties

M.Wt	600.1039
Formula	C34H34ClN3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-, hydrochloride (1:1)

References

1. Hyafil F, et al. Cancer Res. 1993 Oct 1;53(19):4595-602.

2. den Ouden D, et al. Leukemia. 1996 Dec;10(12):1930-6.

3. Witherspoon SM, et al. Clin Cancer Res. 1996 Jan;2(1):7-12.

Elacridar hydrochloride (GF-120918A)

Biological Activity

Physicochemical Properties

References

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