Elaiophylin |CAS:37318-06-2 Probechem Biochemicals

Chemical Structure : Elaiophylin

CAS No.: 37318-06-2

Elaiophylin (Gopalamicin;Salbomycin;Azalomycin B)

Catalog No.: PC-63057Not For Human Use, Lab Use Only.

Elaiophylin (Gopalamicin;Salbomycin;Azalomycin B) is a macrodiolide antibiotic and autophagy inhibitor that promotes autophagosome accumulation.

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1 mg	$328	In stock
2 mg	$528	In stock
5 mg	$858	In stock
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Biological Activity

Elaiophylin (Gopalamicin;Salbomycin;Azalomycin B) is a macrodiolide antibiotic that shows in vitro anti-protozoal activity against both Plasmodium and Trypanosoma (IC50=370 and 460 ng/ml, respectively) and cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50=870 ng/ml).
Elaiophylin also is a novel autophagy inhibitor that promotes autophagosome accumulation but blocks autophagic flux by attenuating lysosomal cathepsin activity, resulting in the accumulation of SQSTM1/p62 in various cell lines.

Physicochemical Properties

M.Wt	1025.3
Formula	C54H88O18
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3E,5E,7S,8S,11E,13E,15S,16S)-8,16-bis[(2S,3R,4S)-4-[(2R,4R,5R,6R)-4-[(2R,4S,5S,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-5-ethyl-2-hydroxy-6-methyloxan-2-yl]-3-hydroxypentan-2-yl]-7,15-dimethyl-1,9-dioxacyclohexadeca-3,5,11,13-tetraene-2,10-dione

References

1. Otoguro K, et al. J Antibiot (Tokyo). 2010 May;63(5):275-7.

2. Zhao X, et al. Autophagy. 2015;11(10):1849-63.

3. Wang G, et al. Cancer Biol Ther. 2017 Jul 18:1-12.

Elaiophylin (Gopalamicin;Salbomycin;Azalomycin B)

Biological Activity

Physicochemical Properties

References

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