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Chemical Structure : Elatol
Catalog No.: PC-35162Not For Human Use, Lab Use Only.
Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.
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Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.
Elatol (NSC 341593) binds in a 2:1 ratio to eIF4A1 (Kd=1.98 uM) and disrupts helicase activity, Elatol is active against eIF4A1’s ATP hydrolysis at 16.4 uM.
Elatol is less potent in vitro than the well-studied eIF4A1 inhibitor silvestrol but is tolerated in vivo at ~100X relative dosing, leading to significant activity against lymphoma xenografts.
| M.Wt | 333.694 | |
| Formula | C15H22BrClO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Peters TL, et al. Clin Cancer Res. 2018 May 29. pii: clincanres.3645.2017.
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