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Elatol

Chemical Structure : Elatol

CAS No.: 55303-97-4

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Elatol (NSC 341593)

Catalog No.: PC-35162Not For Human Use, Lab Use Only.

Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types.
    Elatol (NSC 341593) binds in a 2:1 ratio to eIF4A1 (Kd=1.98 uM) and disrupts helicase activity, Elatol is active against eIF4A1’s ATP hydrolysis at 16.4 uM.
    Elatol is less potent in vitro than the well-studied eIF4A1 inhibitor silvestrol but is tolerated in vivo at ~100X relative dosing, leading to significant activity against lymphoma xenografts.

    Physicochemical Properties

    M.Wt 333.694
    Formula C15H22BrClO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3S,4R,6R)-4-bromo-10-chloro-5,5,9-trimethyl-1-methylidenespiro[5.5]undec-9-en-3-ol

    References

    1. Peters TL, et al. Clin Cancer Res. 2018 May 29. pii: clincanres.3645.2017.

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