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Elbasvir

Chemical Structure : Elbasvir

CAS No.: 1370468-36-2

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Elbasvir (MK-8742, MK8742)

Catalog No.: PC-21353Not For Human Use, Lab Use Only.

Elbasvir (MK-8742) is a potent, tetracyclic indole-based HCV NS5A inhibitor, shows broad HCV genotype activity with IC50 of 0.003, 0.003, 0.004, 0.5, 2.4 nM for genotype 1b, 2a, 1a, 1aL31V and 1aY93H, respectively.

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25 mg $158 In stock
50 mg $248 In stock
100 mg $398 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Elbasvir (MK-8742) is a potent, tetracyclic indole-based HCV NS5A inhibitor, shows broad HCV genotype activity with IC50 of 0.003, 0.003, 0.004, 0.5, 2.4 nM for genotype 1b, 2a, 1a, 1aL31V and 1aY93H, respectively.
Elbasvir (MK-8742) shows an increased potency against clinically relevant resistance variants.
Elbasvir (MK-8742) exhibits antiviral activity against several HCV genotypes (including 1a, 1b, 2a, 3a, 4a) with decreased potency against genotype 2b.

Physicochemical Properties

M.Wt 882.02
Formula C49H55N9O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

dimethyl ((2S,2'S)-((2S,2'S)-(((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-1,2-diyl))dicarbamate

References

1. Coburn CA, et al. ChemMedChem. 2013 Dec;8(12):1930-40.

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