Chemical Structure : Eleclazine hydrochloride
CAS No.: 1448754-43-5
Catalog No.: PC-45068Not For Human Use, Lab Use Only.
A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF).
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Eleclazine (GS6615) hydrochloride is a potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF).
Eleclazine (GS6615) is 42 times more potent than Ranolazine in reducing ischemic burden in vivo (EC50=190 nM).
M.Wt | 451.8262 | |
Formula | C21H17ClF3N3O3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
1,4-Benzoxazepin-5(2H)-one, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]-, hydrochloride (1:1) |
1. Zablocki JA, et al. J. Med. Chem., 2016, 59 (19), pp 9005–9017
2. Fuller H, et al. Heart Rhythm. 2016 Aug;13(8):1679-86.
3. Bacic D, et al. Heart Rhythm. 2017 Mar;14(3):448-454.
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