Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Sodium Channel-Eleclazine hydrochloride
Eleclazine hydrochloride

Chemical Structure : Eleclazine hydrochloride

CAS No.: 1448754-43-5

Eleclazine hydrochloride (GS-6615 hydrochloride, GS6615 hydrochloride)

Catalog No.: PC-45068Not For Human Use, Lab Use Only.

A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF).

Packing Price Stock Quantity
5 mg $158 In stock
10 mg $248 In stock
25 mg $398 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Eleclazine (GS6615) hydrochloride is a potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF).
Eleclazine (GS6615) is 42 times more potent than Ranolazine in reducing ischemic burden in vivo (EC50=190 nM).

Physicochemical Properties

M.Wt 451.8262
Formula C21H17ClF3N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,4-Benzoxazepin-5(2H)-one, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]-, hydrochloride (1:1)

References

1. Zablocki JA, et al. J. Med. Chem., 2016, 59 (19), pp 9005–9017

2. Fuller H, et al. Heart Rhythm. 2016 Aug;13(8):1679-86.

3. Bacic D, et al. Heart Rhythm. 2017 Mar;14(3):448-454.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: