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Chemical Structure : Elevenostat
CAS No.: 1454902-97-6
Catalog No.: PC-72094Not For Human Use, Lab Use Only.
Elevenostat (JB3-22) is a selective HDAC11 inhibitor with IC50 of 0.235 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 250 mg | Get quote |
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Elevenostat (JB3-22) is a selective HDAC11 inhibitor with IC50 of 0.235 uM.
Elevenostat (JB3-22) reversed the inhibitory effects of HDAC11 at the Foxp3 promoter in vitro, also partially reversed the inhibitory effect of HDAC11 on p300-induced Foxp3 acetylation at lysine 31.
HDAC11 targeting with Elevenostat (JB3-22) for post-transplant can promote Treg suppressive activity and lead to long-term allograft survival.
| M.Wt | 315.329 | |
| Formula | C16H17N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-Hydroxy-4-((3-(2-methoxyphenyl)ureido)methyl)benzamide |
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1. Kutil Z, et al. ACS Omega. 2019 Nov 15;4(22):19895-19904.
2. Mostofa A, et al. JCI Insight. 2021 Dec 22;6(24):e151713.
3. Liyan Sui, et al. Cell Cycle. 2020 Feb;19(3):354-362.
4. Huang J, et al. Sci Rep. 2017;7:8626.
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