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Chemical Structure : Eliprodil
Catalog No.: PC-43279Not For Human Use, Lab Use Only.
Eliprodil (SL-820715) is a non-competitive NR2B-NMDA receptor antagonist, less potent for NR2A- and NR2C-containing receptors (IC50>100 uM).
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Eliprodil (SL-820715) is a non-competitive NR2B-NMDA receptor antagonist, less potent for NR2A- and NR2C-containing receptors (IC50>100 uM); inhibits [3H]norepinephrine release from cortical and hippocampal slices but enhances the basal efflux of endogenous and tritiated dopamine from striatal slices, also blocks the uptake of [3H]dopamine into striatal synaptosomes with IC50 of 1.5 uM; reduces the volume of infarction in models of focal cerebral ischemia.
Stroke
Phase 3 Discontinued
| M.Wt | 347.8541 | |
| Formula | C20H23ClFNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Woodward JJ, et al. Eur J Pharmacol. 1992 Jan 21;210(3):265-70.
2. Carter CJ, et al. J Pharmacol Exp Ther. 1990 May;253(2):475-82.
3. Carter C, et al. Eur J Pharmacol. 1989 May 30;164(3):611-2.
4. Bath CP, et al. Eur J Pharmacol. 1996 Mar 28;299(1-3):103-12.
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