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Eloralintide

Chemical Structure : Eloralintide

CAS No.: 2883634-40-8

Eloralintide (LY-3841136, LY3841136)

Catalog No.: PC-24949Not For Human Use, Lab Use Only.

Eloralintide (LY3841136) is a selective amylin mimetic and long acting amylin receptor (AMYR) agonist, binds to amylin receptors with high selectivity from calcitonin receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Eloralintide (LY3841136) is a selective amylin mimetic and long acting amylin receptor (AMYR) agonist, binds to amylin receptors with high selectivity from calcitonin receptors.
Eloralintide (LY3841136) demonstrates prolonged plasma half-life and reduced clearance compared to cagrilintide.
Eloralintide (LY3841136) matched the food intake reductions of cagrilintide, resulting in a similar degree on body weight change, without the same degree of conditioned taste avoidance, in rats。
Eloralintide (LY3841136) lowered body weight primarily by loss of fat mass and with more potent effects for weight loss efficacy, food intake lowering, and fat mass reductions in DIO rats.

Physicochemical Properties

M.Wt 4526.10
Formula C201H319N49O65S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Sequence: {γGlu}-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gly-{Orn}-Leu-Ala-Glu-{(α-Me-Phe)}-Leu-Val-Arg-Ser-Ser-Asn-{(N-Me-Asn)}-Phe-Gly-Pro-{Lys(γGlu-γGlu-C20 diacid)}-Leu-Pro-Pro-Thr-Glu-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Methylene bridge: Cys2-Cys7)

References

1. DANIEL A. BRIERE, et al. Diabetes 2025;74(Supplement_1):849-P.

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