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Eluxadoline

Chemical Structure : Eluxadoline

CAS No.: 864821-90-9

Eluxadoline (JNJ-27018966; JNJ27018966)

Catalog No.: PC-60737Not For Human Use, Lab Use Only.

A potent, selective, orally bioavailable µ-opioid receptor agonist and a δ-opioid receptor antagonist for the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D)..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Eluxadoline (JNJ27018966) is a potent, selective, orally bioavailable µ-opioid receptor agonist and a δ-opioid receptor antagonist for the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D).

    Physicochemical Properties

    M.Wt 569.651
    Formula C32H35N5O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-(((S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)-N-((S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl)propanamido)methyl)-2-methoxybenzoic acid

    References

    1. Dove LS, et al. Gastroenterology. 2013 Aug;145(2):329-38.e1.

    2. Fujita W, et al. Biochem Pharmacol. 2014 Dec 1;92(3):448-56.

    3. Davenport JM, et al. J Clin Pharmacol. 2015 May;55(5):534-42.

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