Chemical Structure : Elvitegravir
CAS No.: 697761-98-1
Catalog No.: PC-23743Not For Human Use, Lab Use Only.
Elvitegravir (JTK-303, GS-9137) is a potent, selective HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 7.2 nM in 7.2 nM in the strand transfer assay and EC50 of 0.9 nM in acute HIV-1 infection assay.
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Elvitegravir (JTK-303, GS-9137) is a potent, selective HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 7.2 nM in 7.2 nM in the strand transfer assay and EC50 of 0.9 nM in acute HIV-1 infection assay.
Elvitegravir blocks strand transfer by viral integrase enzyme.
Elvitegravir inhibits HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
M.Wt | 447.89 | |
Formula | C23H23ClFNO5 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(S)-6-(3-Chloro-2-fluorobenzyl)-1-(1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
1. Shimura K, et al. J Virol. 2008 Jan;82(2):764-74.
2. Sato M, et al. J Med Chem. 2006 Mar 9;49(5):1506-8.
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