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Empagliflozin

Chemical Structure : Empagliflozin

CAS No.: 864070-44-0

Empagliflozin (BI-10773, BI 10773)

Catalog No.: PC-22576Not For Human Use, Lab Use Only.

Empagliflozin (BI-10773) is a potent, selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with IC50 of 3.1 nM (hSGLT-2), has a high degree of selectivity over SGLT-1, 4, 5 and 6, has potential for the oral treatment of type 2 diabetes mellitus (T2DM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Empagliflozin (BI-10773) is a potent, selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with IC50 of 3.1 nM (hSGLT-2). has a high degree of selectivity over SGLT-1, 4, 5 and 6, has potential for the oral treatment of type 2 diabetes mellitus (T2DM).

Physicochemical Properties

M.Wt 450.91
Formula C23H27ClO7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

References

1. Aires I, et al. Curr Opin Investig Drugs. 2010 Oct;11(10):1182-90.

2. Grempler R, et al. Diabetes Obes Metab. 2012 Jan;14(1):83-90.

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