Catalog No.: PC-73415Not For Human Use, Lab Use Only.
Emprumapimod (PF-07265803) is a potent, selective and orally bioavailable inhibitor of p38 MAPK, inhibits LPS-induced IL-6 production in RPMI-8226 cells with IC50 of 0.1 nM.
Emprumapimod (PF-07265803) is a potent, selective and orally bioavailable inhibitor of p38 MAPK, inhibits LPS-induced IL-6 production in RPMI-8226 cells with IC50 of 0.1 nM.
Emprumapimod (PF-07265803) (30 mg/kg, p.o.) inhibited LPS induced IL-6 and TNF-alpha by 91% and 95% in SCID-beige mice.
Emprumapimod (PF-07265803) (30 mg/kg, BID, PO) inhibited RPMI 8226 tumor growth by 72% as a single agent in MM xenograft models.
Emprumapimod (PF-07265803) inhibited LPS-induced phosphorylation of p38 in RPMI-8226 xenografts.
