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Chemical Structure : Enadoline
Catalog No.: PC-62107Not For Human Use, Lab Use Only.
Enadoline (CI 977.
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Enadoline (CI 977;PD 129290) is a potent, selective κ-opioid receptor (KOR) agonist with Ki of 0.11 nM, binding with high affinity to [3H]-U69593-labelled kappa-sites; produces a potent inhibition of the electrically-evoked contractions of the guinea-pig ileum and rabbit vas deferens with IC50 values of 0.087 nM and 3.3 nM, respectively; is effective in reducing infarction in a model of focal cerebral ischaemia.
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Phase 2 Discontinued
| M.Wt | 396.531 | |
| Formula | C24H32N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hunter JC, et al. Br J Pharmacol. 1990 Sep;101(1):183-9.
2. Singh L, et al. Eur J Pharmacol. 1990 Dec 4;191(3):477-80.
3. Kusumoto K, et al. Brain Res. 1992 Mar 27;576(1):147-51.
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