Enadoline | KOR agonist | Probechem Biochemicals

Chemical Structure : Enadoline

Enadoline (CI 977, PD 129290)

Catalog No.: PC-62107Not For Human Use, Lab Use Only.

Enadoline (CI 977, PD 129290) is a potent, selective κ-opioid receptor (KOR) agonist with Ki of 0.11 nM, binding with high affinity to [3H]-U69593-labelled kappa-sites.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Enadoline (CI 977, PD 129290) is a potent, selective κ-opioid receptor (KOR) agonist with Ki of 0.11 nM, binding with high affinity to [3H]-U69593-labelled kappa-sites.
Enadoline produces a potent inhibition of the electrically-evoked contractions of the guinea-pig ileum and rabbit vas deferens with IC50 values of 0.087 nM and 3.3 nM, respectively.
Enadoline is effective in reducing infarction in a model of focal cerebral ischaemia.

Physicochemical Properties

M.Wt	396.531
Formula	C24H32N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-benzofuran-4-yl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide

References

1. Hunter JC, et al. Br J Pharmacol. 1990 Sep;101(1):183-9.

2. Singh L, et al. Eur J Pharmacol. 1990 Dec 4;191(3):477-80.

3. Kusumoto K, et al. Brain Res. 1992 Mar 27;576(1):147-51.

Enadoline (CI 977, PD 129290)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.