Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Encequidar mesylate monohydrate
Catalog No.: PC-73219Not For Human Use, Lab Use Only.
Encequidar (HM30181) mesylate monohydrate is a potent selective inhibitor of MDR1 (ABCB1, P-gp) with IC50 of 0.63 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Encequidar (HM30181) mesylate monohydrate is a potent selective inhibitor of MDR1 (ABCB1, P-gp) with IC50 of 0.63 nM.
Encequidar (HM30181) effectively blocked transepithelial transport of paclitaxel in MDCK monolayers.
Encequidar (HM30181) does not inhibit MRP1 (ABCC1), MRP2 (ABCC2), and MRP3 (ABCC3), and partially inhibited BCRP (ABCG2) only at very high concentrations.
Oral co-administration of paclitaxel and HM30181 showed a tumor-inhibitory strength equal or superior to that of intravenous paclitaxel in the xenograft model in nude mice.
| M.Wt | 802.856 | |
| Formula | C39H42N6O11S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kim TE, et al. Br J Clin Pharmacol. 2014 Sep;78(3):556-64.
2. Bauer F, et al. Eur J Pharmacol. 2012 Dec 5;696(1-3):18-27.
3. Kwak JO, et al. Eur J Pharmacol. 2010 Feb 10;627(1-3):92-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
