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Enzalutamide

Chemical Structure : Enzalutamide

CAS No.: 915087-33-1

Enzalutamide (MDV3100, MDV-3100)

Catalog No.: PC-45932Not For Human Use, Lab Use Only.

Enzalutamide (MDV3100) is a potent, selective and orally available androgen-receptor (AR) antagonist with IC50 of 36 nM.

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Biological Activity

Enzalutamide (MDV3100) is a potent, selective and orally available androgen-receptor (AR) antagonist with IC50 of 36 nM.
Enzalutamide (MDV3100) reduces the efficiency of AR nuclear translocation, and impairs both DNA binding to androgen response elements and recruitment of coactivators.
Enzalutamide (MDV3100) induces tumor regression in mouse models of castration-resistant human prostate cancer.

Physicochemical Properties

M.Wt 464.4359
Formula C21H16F4N4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-

References

1. Tran C, et al. Science. 2009 May 8;324(5928):787-90.

2. Richards J, et al. Cancer Res. 2012 May 1;72(9):2176-82.

3. Scher HI, et al. N Engl J Med. 2012 Sep 27;367(13):1187-97.

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