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Chemical Structure : Enzalutamide
CAS No.: 915087-33-1
Catalog No.: PC-45932Not For Human Use, Lab Use Only.
Enzalutamide (MDV3100) is a potent, selective and orally available androgen-receptor (AR) antagonist with IC50 of 36 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $178 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | $458 | In stock | |
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Enzalutamide (MDV3100) is a potent, selective and orally available androgen-receptor (AR) antagonist with IC50 of 36 nM.
Enzalutamide (MDV3100) reduces the efficiency of AR nuclear translocation, and impairs both DNA binding to androgen response elements and recruitment of coactivators.
Enzalutamide (MDV3100) induces tumor regression in mouse models of castration-resistant human prostate cancer.
| M.Wt | 464.4359 | |
| Formula | C21H16F4N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl- |
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1. Tran C, et al. Science. 2009 May 8;324(5928):787-90.
2. Richards J, et al. Cancer Res. 2012 May 1;72(9):2176-82.
3. Scher HI, et al. N Engl J Med. 2012 Sep 27;367(13):1187-97.
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