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Chemical Structure : Epetraborole hydrochloride
CAS No.: 1234563-16-6
Catalog No.: PC-43054Not For Human Use, Lab Use Only.
Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 25 mg | $580 | In stock | |
| 100 mg | $1380 | In stock | |
| 500 mg | Get quote |
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Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates; MIC90s against 302 Bacteroides fragilis and Bacteroides thetaiotaomicron strains are 4 and 8 μg/ml, respectively; a single amino acid polymorphism (P329) within the editing domain of LeuRS reduces susceptibility to GSK2251052.
Bacterial Infection
Phase 2 Discontinued
| M.Wt | 273.521 | |
| Formula | C11H17BClNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
1-Propanol, 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-, hydrochloride (1:1) |
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1. Goldstein EJ, et al. Antimicrob Agents Chemother. 2013 May;57(5):2401-4.
2. Tenero D, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3334-9.
3. O'Dwyer K, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.
4. Gupta A, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3219-21.
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