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Chemical Structure : Epolactaene
Catalog No.: PC-61905Not For Human Use, Lab Use Only.
Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells.
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Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells.
Epolactaene inhibits DNA topoisomerase II (topo II), binds to Hsp60 Cys442 resulting in the inhibition of chaperone activity.
Epolactaene also reacts with N-acetylcysteine methyl ester and induces the disulfide formation.
| M.Wt | 389.45 | |
| Formula | C21H27NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kakeya H, et al. J Antibiot (Tokyo). 1995 Jul;48(7):733-5.
2. Nagumo Y, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4425-9.
3. Nagumo Y, et al. Biochem J. 2005 May 1;387(Pt 3):835-40.
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