Epolactaene |Topo II inhibitor Probechem Biochemicals

Chemical Structure : Epolactaene

Epolactaene

Catalog No.: PC-61905Not For Human Use, Lab Use Only.

Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells.

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Biological Activity

Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells.
Epolactaene inhibits DNA topoisomerase II (topo II), binds to Hsp60 Cys442 resulting in the inhibition of chaperone activity.
Epolactaene also reacts with N-acetylcysteine methyl ester and induces the disulfide formation.

Physicochemical Properties

M.Wt	389.45
Formula	C21H27NO6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (2E,3E,5E,9E)-2-ethylidene-11-[(1R,5R)-4-hydroxy-4-methyl-2-oxo-6-oxa-3-azabicyclo[3.1.0]hexan-1-yl]-4,10-dimethyl-11-oxoundeca-3,5,9-trienoate

References

1. Kakeya H, et al. J Antibiot (Tokyo). 1995 Jul;48(7):733-5.

2. Nagumo Y, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4425-9.

3. Nagumo Y, et al. Biochem J. 2005 May 1;387(Pt 3):835-40.

Epolactaene

Biological Activity

Physicochemical Properties

References

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