Epothilone A | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : Epothilone A

CAS No.: 152044-53-6

Epothilone A (Epo A)

Catalog No.: PC-20928Not For Human Use, Lab Use Only.

Epothilone A (Epo A) is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers with Ki of 0.6-1.4 uM.

Packing	Price	Stock
10 mg	$218	In stock
25 mg	$388	In stock
50 mg	$588	In stock
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1 g		Get quote

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Biological Activity

Epothilone A (Epo A) is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers with Ki of 0.6-1.4 uM.
Epothilone A (Epo A) shows highly cytotoxic effect (IC50=0.05 μM) in vitro of human T-24 bladder carcinoma cell line.

Physicochemical Properties

M.Wt	493.66
Formula	C26H39NO6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3([H])CCC[C@H](C)[C@H](O)[C@@H](C)C1=O

References

1. Kowalski RJ, et al. J Biol Chem. 1997 Jan 24;272(4):2534-41.

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Epothilone A (Epo A)

Biological Activity

Physicochemical Properties

References

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