Chemical Structure : Ercalcitriol
CAS No.:
60133-18-8
Ercalcitriol
(1,25-Dihydroxyvitamin D2;1,25-Dihydroxycalciferol)
Catalog No. : PC-45808Not For Human Use, Lab Use Only.
The active circulating metabolite of vitamin D2 that binds to nuclear receptor VDR.
Packing Price Stock Quantity 5 mg $352 In stock 0 1 2 3 4 5 10 mg $632 In stock 0 1 2 3 4 5 25 mg $1328 In stock 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4580801
Biological Activity
The active circulating metabolite of vitamin D2 that binds to nuclear receptor VDR; activates VDR to interact with retinoid X receptor (RXR) and forms the VDR/RXR/cofactor complex, which binds to Vitamin D response elements in the promoter region of target genes to regulate gene transcription.
Physicochemical Properties
M.Wt
428.6472
Formula
C28H44O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
References
1. Nakane M, et al. J Steroid Biochem Mol Biol. 2006 Jan;98(1):72-7.
2. Hollis BW. Nutr Rev. 2007 Aug;65(8 Pt 2):S87-90.
3. Hollis BW, et al. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):473-6.
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