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Chemical Structure : Erenumab
CAS No.:
Catalog No.: PC-Ab1070Not For Human Use, Lab Use Only.
Erenumab (AMG-334) is a fully human monoclonal antibody that selectively and potently binds to the canonical CGRP (calcitonin gene-related peptide receptor). Erenumab (AMG-334) competes with [(125)I]-CGRP binding to the human CGRP receptor, with a Ki of 0.02 nM. AMG 334 fully inhibited CGRP-stimulated cAMP production with an IC50 of 2.3 nM in cell-based functional assays (human CGRP receptor) and was 5000-fold more selective for the CGRP receptor than other human calcitonin family receptors, inc
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $358 | In stock | |
| 5 mg | $758 | In stock | |
| 10 mg | $1280 | In stock | |
| 100 mg | Get quote |
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Erenumab (AMG-334) is a fully human monoclonal antibody that selectively and potently binds to the canonical CGRP (calcitonin gene-related peptide receptor). Erenumab (AMG-334) competes with [(125)I]-CGRP binding to the human CGRP receptor, with a Ki of 0.02 nM. AMG 334 fully inhibited CGRP-stimulated cAMP production with an IC50 of 2.3 nM in cell-based functional assays (human CGRP receptor) and was 5000-fold more selective for the CGRP receptor than other human calcitonin family receptors, including adrenomedullin, calcitonin, and amylin receptors. Erenumab blocks the activation of calcitonin gene-related peptide (CGRP), which can cause blood vessels to dilate and ellicit inflammation and migraine headache pain. Erenumab is used to prevent migraine headaches in adults.
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| Formula | Human IgG2-Lambda | |
| Appearance | Solid | |
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PBS, pH 7.0 Contains no stabilizers or preservatives |
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