Chemical Structure : Eribaxaban
CAS No.:
536748-46-6
Eribaxaban
(PD-0348292;PD0348292;PD 0348292)
Catalog No.: PC-60954Not For Human Use, Lab Use Only.
A potent, selective and orally efficacious factor Xa (FXa) inhibitor with IC50 of 0.32 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
A potent, selective and orally efficacious factor Xa (FXa) inhibitor with IC50 of 0.32 nM; displays >1,000-fold selectivity over a series of related serine proteases (thrombin, activated protein C, plasmin, tissue plasminogen activator and trypsin); potently inhibits thrombosis and shows potential for s for the treatment and prevention of thrombotic disorders.
Thrombosis
Phase 2 Discontinued
Physicochemical Properties
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M.Wt
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484.912
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Formula
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C24H22ClFN4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R,4R)-1-N-(4-chlorophenyl)-2-N-[2-fluoro-4-(2-oxopyridin-1-yl)phenyl]-4-methoxypyrrolidine-1,2-dicarboxamide
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References
1. Kohrt JT, et al. Chem Biol Drug Des. 2007 Aug;70(2):100-12.
2. McBane RD 2nd, et al. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):413-8.
3. Karnicki K, et al. Thromb Haemost. 2008 Apr;99(4):759-66.
4. Cohen AT, et al. J Thromb Haemost. 2013 Aug;11(8):1503-10.
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