Eribulin | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : Eribulin

CAS No.: 253128-41-5

Eribulin (B1939, E7389, ER-086526)

Catalog No.: PC-43536Not For Human Use, Lab Use Only.

Packing	Price	Stock
1 mg	$198	In stock
5 mg	$398	In stock
10 mg	$598	In stock
25 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Eribulin (B1939, E7389, ER-086526) is a macrocyclic ketone analogue of halichondrir B, shows sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines via inhibition of tubulin polymerization.
Eribulin induces G2-M cell cycle arrest and disruption of mitotic spindles.
Eribulin demonstrates marked in vivo activities at 0.1-1 mg/kg against human xenografts: MDA-MB-435 breast cancer, COLO 205 colon cancer, LOX melanoma, and NIH: OVCAR-3 ovarian cancer.

Physicochemical Properties

M.Wt	729.8965
Formula	C40H59NO11
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	11,15:18,21:24,28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one, 2-[(2S)-3-amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-, (2R,3R,3aS,7R,8aS,9S,10aR,11S,1

References

1. Towle MJ, et al. Cancer Res. 2001 Feb 1;61(3):1013-21.

2. Vahdat LT, et al. J Clin Oncol. 2009 Jun 20;27(18):2954-61.

3. Okouneva T, et al. Mol Cancer Ther. 2008 Jul;7(7):2003-11.

4. Zheng W, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5551-4.

Eribulin (B1939, E7389, ER-086526)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.