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Chemical Structure : Eribulin
CAS No.: 253128-41-5
Catalog No.: PC-43536Not For Human Use, Lab Use Only.
Eribulin (B1939, E7389, ER-086526) is a macrocyclic ketone analogue of halichondrir B, shows sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines via inhibition of tubulin polymerization.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $198 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Eribulin (B1939, E7389, ER-086526) is a macrocyclic ketone analogue of halichondrir B, shows sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines via inhibition of tubulin polymerization.
Eribulin induces G2-M cell cycle arrest and disruption of mitotic spindles.
Eribulin demonstrates marked in vivo activities at 0.1-1 mg/kg against human xenografts: MDA-MB-435 breast cancer, COLO 205 colon cancer, LOX melanoma, and NIH: OVCAR-3 ovarian cancer.
| M.Wt | 729.8965 | |
| Formula | C40H59NO11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
11,15:18,21:24,28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one, 2-[(2S)-3-amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-, (2R,3R,3aS,7R,8aS,9S,10aR,11S,1 |
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1. Towle MJ, et al. Cancer Res. 2001 Feb 1;61(3):1013-21.
2. Vahdat LT, et al. J Clin Oncol. 2009 Jun 20;27(18):2954-61.
3. Okouneva T, et al. Mol Cancer Ther. 2008 Jul;7(7):2003-11.
4. Zheng W, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5551-4.
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