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Eribulin mesylate

Chemical Structure : Eribulin mesylate

CAS No.: 441045-17-6

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Eribulin mesylate (B1939 mesylate, E7389 mesylate, ER-086526 mesylate)

Catalog No.: PC-43537Not For Human Use, Lab Use Only.

Eribulin mesylate (B1939, E7389, ER-086526) is a macrocyclic ketone analogue of halichondrir B, shows sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines via inhibition of tubulin polymerization.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Eribulin mesylate (B1939, E7389, ER-086526) is a macrocyclic ketone analogue of halichondrir B, shows sub-nM growth inhibitory activities in vitro against numerous human cancer cell lines via inhibition of tubulin polymerization.
Eribulin induces G2-M cell cycle arrest and disruption of mitotic spindles.
Eribulin demonstrates marked in vivo activities at 0.1-1 mg/kg against human xenografts: MDA-MB-435 breast cancer, COLO 205 colon cancer, LOX melanoma, and NIH: OVCAR-3 ovarian cancer.

Physicochemical Properties

M.Wt 826.0022
Formula C41H63NO14S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

11,15:18,21:24,28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one, 2-[(2S)-3-amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-, (2R,3R,3aS,7R,8aS,9S,10aR,11S,1

References

1. Towle MJ, et al. Cancer Res. 2001 Feb 1;61(3):1013-21.

2. Vahdat LT, et al. J Clin Oncol. 2009 Jun 20;27(18):2954-61.

3. Okouneva T, et al. Mol Cancer Ther. 2008 Jul;7(7):2003-11.

4. Zheng W, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5551-4.

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