Catalog No.: PC-61435Not For Human Use, Lab Use Only.
Estrone sulfamate (Estrone 3-O-Sulfamate, EMATE) is a potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells.
Estrone sulfamate (Estrone 3-O-Sulfamate, EMATE) is a potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells.
Estrone sulfamate inhibits tissue E1-STS activity in rats by more than 95% at 10 mg/kg.
Estrone sulfamate exhibits potential applications in the treatment of ER-positive breast cancer and certain other conditions.
