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Estrone sulfamate

Chemical Structure : Estrone sulfamate

CAS No.: 148672-09-7

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Estrone sulfamate (Estrone 3-O-Sulfamate;EMATE)

Catalog No.: PC-61435Not For Human Use, Lab Use Only.

A potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells; inhibits tissue E1-STS activity in rats by more than 95% at 10 mg/kg; exhibits potential applications in the treatment of ER-positive breast cancer and certain other conditions.

Physicochemical Properties

M.Wt 349.44
Formula C18H23NO4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[(Aminosulfonyl)oxy]estra-1,3,5(10)-trien-17-one

References

1. Purohit A, et al. J Steroid Biochem Mol Biol. 1994 Jul;50(1-2):101-4.

2. Woo LW, et al. J Med Chem. 1998 Mar 26;41(7):1068-83.

3. Woo LL, et al. Chem Biol. 2000 Oct;7(10):773-91.

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