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Etodolac

Chemical Structure : Etodolac

CAS No.: 41340-25-4

Etodolac (AY-24236, AY24236)

Catalog No.: PC-45966Not For Human Use, Lab Use Only.

Etodolac (AY-24236) is a nonsteroidal anti-inflammatory drug that acts as a non-selective inhibitor of COX with IC50 of 53.5 nM.

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Biological Activity

Etodolac (AY-24236) is a nonsteroidal anti-inflammatory drug that acts as a non-selective inhibitor of COX with IC50 of 53.5 nM.
Etodolac (AY-24236) also inhibits PGHS-2 and shows 10-fold selectivity over PGHS-1.
Etodolac (AY-24236) exhibits 10-fold selectivity for inhibition of PGHS-2 mediated TxB2 production in a human whole blood assay.
Etodolac is licensed for the treatment of inflammation and pain caused by osteoarthritis and rheumatoid arthritis.

Physicochemical Properties

M.Wt 287.3535
Formula C17H21NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Pyrano[3,4-b]indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-

References

1. Ito S, et al. J Pharmacol Exp Ther. 2012 Jul;342(1):53-60.

2. Glaser K, et al. Eur J Pharmacol. 1995 Jul 25;281(1):107-11.

3. Suyama H, et al. Brain Res. 2004 Jun 4;1010(1-2):144-50.

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