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Chemical Structure : Evacetrapib
CAS No.: 1186486-62-3
Catalog No.: PC-43496Not For Human Use, Lab Use Only.
Evacetrapib (LY2484595) is a potent and selective inhibitor of cholesteryl ester transfer protein (CETP) with IC50of 5.5 nM for human recombinant CETP protein.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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Evacetrapib (LY2484595) is a potent and selective inhibitor of cholesteryl ester transfer protein (CETP) with IC50 of 5.5 nM for human recombinant CETP protein.
Evacetrapib (LY2484595) inhibits CETP activity in human plasma with IC50 of 36 nM.
Evacetrapib (LY2484595) shows no significant inhibition in the CEREP cell surface receptor screening, as well as the nuclear receptor panel.
Evacetrapib (LY2484595) exhibits an ex vivo CETP inhibition ED50 of < 5 mg/kg at 8 h post oral dose and significantly elevates HDL cholesterol in vivo.
Evacetrapib (LY2484595) is a potent and selective CETP inhibitor without torcetrapib-like off-target liabilities.
| M.Wt | 638.65 | |
| Formula | C31H36F6N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclohexanecarboxylic acid, 4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-, trans- |
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1. Cao G, et al. J Lipid Res. 2011 Dec;52(12):2169-76.
2. Nicholls SJ, et al. JAMA. 2011 Nov 16;306(19):2099-109.
3. Barter PJ, et al. J Lipid Res. 2012 Sep;53(9):1755-66.
4. Suico JG, et al. J Cardiovasc Pharmacol Ther. 2014 May;19(3):283-9.
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