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Evobrutinib

Chemical Structure : Evobrutinib

CAS No.: 1415823-73-2

Evobrutinib (M2951;MSC2364447C;MSC 2364447)

Catalog No.: PC-42336Not For Human Use, Lab Use Only.

Evobrutinib (M2951, MSC2364447C, MSC 2364447) is a potent, highly selective, covalent and oral BTK inhibitor with enzyme IC50 of 8.9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Evobrutinib (M2951, MSC2364447C, MSC 2364447) is a potent, highly selective, covalent and oral BTK inhibitor with enzyme IC50 of 8.9 nM.
Evobrutinib shows IC50 of 61 nM in the human peripheral blood mononuclear cell (PBMC) assay.
Evobrutinib shows high selectivity for BTK over epidermal growth factor receptor and other Tec family kinases.
Evobrutinib shows potential in several autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus.

Physicochemical Properties

M.Wt 429.51418
Formula C25H27N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.4 mg/mL (Need ultrasonic)

Chemical Name/SMILES

2-Propen-1-one, 1-[4-[[[6-amino-5-(4-phenoxyphenyl)-4-pyrimidinyl]amino]methyl]-1-piperidinyl]-

References

1. Patent US20140162983 example 0174.
2. Caldwell RD, et al. J Med Chem. 2019 Sep 12;62(17):7643-7655.

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