Evobrutinib |CAS:1415823-73-2 Probechem Biochemicals

Chemical Structure : Evobrutinib

CAS No.: 1415823-73-2

Catalog No.: PC-42336Not For Human Use, Lab Use Only.

Evobrutinib (M2951, MSC2364447C, MSC 2364447) is a potent, highly selective, covalent and oral BTK inhibitor with enzyme IC50 of 8.9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Evobrutinib (M2951, MSC2364447C, MSC 2364447) is a potent, highly selective, covalent and oral BTK inhibitor with enzyme IC50 of 8.9 nM.

Evobrutinib shows IC50 of 61 nM in the human peripheral blood mononuclear cell (PBMC) assay.

Evobrutinib shows high selectivity for BTK over epidermal growth factor receptor and other Tec family kinases.

Evobrutinib shows potential in several autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus.

M.Wt	429.51418
Formula	C25H27N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 6.4 mg/mL (Need ultrasonic)
Chemical Name/SMILES	2-Propen-1-one, 1-[4-[[[6-amino-5-(4-phenoxyphenyl)-4-pyrimidinyl]amino]methyl]-1-piperidinyl]-

1. Patent US20140162983 example 0174.
2. Caldwell RD, et al. J Med Chem. 2019 Sep 12;62(17):7643-7655.