Evofosfamide (TH-302) | DNA alkylating agent

Chemical Structure : Evofosfamide

CAS No.: 918633-87-1

Evofosfamide (TH302, TH-302)

Catalog No.: PC-42644Not For Human Use, Lab Use Only.

Evofosfamide (TH-302) is a potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard, DNA-alkylating agent.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
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Biological Activity

Evofosfamide (TH-302) is a potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard, DNA-alkylating agent.
Evofosfamide (TH-302) is selectively potent under hypoxia and stable to liver microsomes.
Evofosfamide (TH-302) inhibits H246 cells and HT29 cells with IC50 of 0.1 uM and 0.2 uM respectively.
Evofosfamide (TH-302) is active in an in vivo MIA PaCa-2 pancreatic cancer orthotopic xenograft model.

Physicochemical Properties

M.Wt	449.0362
Formula	C9H16Br2N5O4P
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO; H2O: 0.14 mg/mL
Chemical Name/SMILES	Phosphorodiamidic acid, N,N'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester

References

1. Duan JX, et al. J Med Chem. 2008 Apr 24;51(8):2412-20.

2. Hu J, et al. Blood. 2010 Sep 2;116(9):1524-7.

3. Meng F, et al. Mol Cancer Ther. 2012 Mar;11(3):740-51.

Evofosfamide (TH302, TH-302)

Biological Activity

Physicochemical Properties

References

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