Exatecan | ADC payload, Topo I inhibitor

Chemical Structure : Exatecan

CAS No.: 171335-80-1

Exatecan (DX-8951, DX8951)

Catalog No.: PC-28464Not For Human Use, Lab Use Only.

Exatecan (DX-8951) is a potent DNA topoisomerase I (Topo I) inhibitor with IC50 of 2.2 μM (0.975 μg/mL), exerts its cytotoxic effect by trapping the TOP1-DNA cleavage complex (TOP1cc), is a cytotoxic payload for ADCs.

Packing	Price	Stock
50 mg	$38	In stock
100 mg	$58	In stock
250 mg	$88	In stock
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Biological Activity

Physicochemical Properties

M.Wt	435.46
Formula	C24H22FN3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione

References

1. Mitsui I, et al. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

2. Sun FX, et al. Cancer Res. 2003 Jan 1;63(1):80-5.

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Exatecan (DX-8951, DX8951)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

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